Scientific Articles

Important Scientific Articles

Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients with Severe Trauma


The PROPPR Randomized Clinical Trial John B. Holcomb, MD; Barbara C. Tilley, PhD; Sarah Baraniuk, PhD; et al. for the PROPPR Study Group
JAMA. 2015;313(5):471-482. doi:10.1001/jama.2015.12

A PDF-file for downloading available at: http://jama.jamanetwork.com/article.aspx?articleid=2107789
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25647203

Albumin Replacement in Patients with Severe Sepsis or Septic Shock


Pietro Caironi, M.D., Gianni Tognoni, M.D., Serge Masson, Ph.D., et al. for the ALBIOS Study Investigators
N Engl J Med 2014; 370:1412-1421 April 10, 2014 DOI: 10.1056/NEJMoa1305727

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa1305727
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24635772

Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest.


Nielsen N, Wetterslev J, Cronberg T, et al.; TTM Trial Investigators.
N Engl J Med. 2013 Dec 5;369(23):2197-206. doi: 10.1056/NEJMoa1310519. Epub 2013 Nov 17.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa1310519
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24237006

Prone Positioning in Severe Acute Respiratory Distress Syndrome.


Guérin C, Reignier J, Richard JC, et al.; PROSEVA Study Group.
N Engl J Med. 2013 Jun 6;368(23):2159-68. doi: 10.1056/NEJMoa1214103. Epub 2013 May 20.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa1214103
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23688302

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012.


Dellinger RP, Levy MM, Rhodes A, et al.; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup.
Crit Care Med. 2013 Feb;41(2):580-637. doi: 10.1097/CCM.0b013e31827e83af.

Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23353941

Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care.


Myburgh JA, Finfer S, Bellomo R, et al.; CHEST Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group.
N Engl J Med. 2012 Nov 15;367(20):1901-11. doi: 10.1056/NEJMoa1209759. Epub 2012 Oct 17.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa1209759
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23075127

Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis.


Perner A, Haase N, Guttormsen AB, et al.; 6S Trial Group; Scandinavian Critical Care Trials Group.
N Engl J Med. 2012 Jul 12;367(2):124-34. doi: 10.1056/NEJMoa1204242. Epub 2012 Jun 27.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa1204242
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/22738085

Early versus Late Parenteral Nutrition in Critically Ill Adults.


Casaer MP, Mesotten D, Hermans G, et al.
N Engl J Med. 2011 Aug 11;365(6):506-17. doi: 10.1056/NEJMoa1102662. Epub 2011 Jun 29.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa1102662
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/21714640

Vasopressors for hypotensive shock.


Havel C, Arrich J, Losert H, Gamper G, Müllner M, Herkner H.
Cochrane Database Syst Rev. 2011 May 11;(5):CD003709. doi: 10.1002/14651858.CD003709.pub3.

Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/21563137

Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial.


Morrison CA, Carrick MM, Norman MA, et al.
J Trauma. 2011 Mar;70(3):652-63. doi: 10.1097/TA.0b013e31820e77ea.

Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/21610356

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial


CRASH-2 trial collaborators
The Lancet 2010; 376: 23–32.

A PDF-file for downloading available at: http://www.thelancet.com/crash-2-2010
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/20554319

Comparison of Dopamine and Norepinephrine in the Treatment of Shock.


De Backer D, Biston P, Devriendt J, et al.; SOAP II Investigators.
N Engl J Med. 2010 Mar 4;362(9):779-89. doi: 10.1056/NEJMoa0907118.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa0907118
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/20200382

Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients.


RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, Cole L, et al.
N Engl J Med. 2009 Oct 22;361(17):1627-38. doi: 10.1056/NEJMoa0902413.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa0902413
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19846848

Intensive versus Conventional Glucose Control in Critically Ill Patients.


NICE-SUGAR Study Investigators, Finfer S, Chittock DR, Su SY, et al.
N Engl J Med. 2009 Mar 26;360(13):1283-97. doi: 10.1056/NEJMoa0810625. Epub 2009 Mar 24.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa0810625
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19318384

Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock.


Russell JA, Walley KR, Singer J, et al.; VASST Investigators.
N Engl J Med. 2008 Feb 28;358(9):877-87. doi: 10.1056/NEJMoa067373.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa067373
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/18305265

Hydrocortisone Therapy for Patients with Septic Shock.


Sprung CL, Annane D, Keh D, et al.; CORTICUS Study Group.
N Engl J Med. 2008 Jan 10;358(2):111-24. doi: 10.1056/NEJMoa071366.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa071366
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/18184957

Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006.


Antonelli M, Levy M, Andrews PJ, et al.
Intensive Care Med. 2007 Apr;33(4):575-90.

Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/17285286

Duration of Hypotension Before Initiation of Effective Antimicrobial Therapy Is the Critical Determinant of Survival in Human Septic Shock.


Kumar A, Roberts D, Wood KE, et al.
Crit Care Med. 2006 Jun;34(6):1589-96.

Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/16625125

Comparison of Two Fluid-Management Strategies in Acute Lung Injury.


National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Wiedemann HP, Wheeler AP, Bernard GR, et al.
N Engl J Med. 2006 Jun 15;354(24):2564-75. Epub 2006 May 21.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa062200
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/16714767

Pulmonary-Artery versus Central Venous Catheter to Guide Treatment of Acute Lung Injury.


National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Wheeler AP, Bernard GR, Thompson BT, et al.
N Engl J Med. 2006 May 25;354(21):2213-24. Epub 2006 May 21.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa061895
Länk i PubMed: http://www.ncbi.nlm.nih.gov/pubmed/16714768

A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit.


Finfer S, Bellomo R, Boyce N, et al.; SAFE Study Investigators.
N Engl J Med. 2004 May 27;350(22):2247-56.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa040232
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/15163774

Effect of Treatment with Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients with Septic Shock.


Annane D, Sébille V, Charpentier C, et al.
JAMA. 2002 Aug 21;288(7):862-71.

A PDF-file for downloading available at: http://jama.jamanetwork.com/article.aspx?articleid=195197
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/12186604

Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest.


Hypothermia after Cardiac Arrest Study Group.
N Engl J Med. 2002 Feb 21;346(8):549-56.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa012689
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/11856793

Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock.


Rivers E, Nguyen B, Havstad S, et al.; Early Goal-Directed Therapy Collaborative Group.
N Engl J Med. 2001 Nov 8;345(19):1368-77.

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJMoa010307
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/11794169

Intensive Insulin Therapy in Critically Ill Patients.


van den Berghe G, Wouters P, Weekers F, et al.
N Engl J Med. 2001 Nov 8;345(19):1359-67.

PDF-file for downloading available at this link: http://www.nejm.org/doi/full/10.1056/NEJMoa011300
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/11794168

Effect of Norepinephrine on the Outcome of Septic Shock.


Martin C, Viviand X, Leone M, Thirion X.
Crit Care Med. 2000 Aug;28(8):2758-65.

Link in PubMed:http://www.ncbi.nlm.nih.gov/pubmed/10966247

Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome


The Acute Respiratory Distress Syndrome Network
N Engl J Med. 2000; 342:1301-1308. May 4, 2000 DOI: 10.1056/NEJM200005043421801

A PDF-file for downloading available at: http://www.nejm.org/doi/full/10.1056/NEJM200005043421801
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/10793162

'Damage control': an approach for improved survival in exsanguinating penetrating abdominal injury.


Rotondo MF, Schwab CW, McGonigal MD, Phillips GR 3rd, Fruchterman TM, Kauder DR, Latenser BA, Angood PA.
J Trauma 1993 Sep;35(3):375-82; discussion 382-3.

Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/8371295